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Compare 435 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Magnuson Hotel Wildwood Inn
3.0 star property
8.6 out of 10, Excellent, 1,006 reviews
"Friendly staff and very clean room "
The price is $116
$134 total
includes taxes & fees
Jun 23 - Jun 24
Magnuson Hotel Wildwood Inn
The Lodge at Wakulla Springs
3.0 star property
9.2 out of 10, Wonderful, 752 reviews
"The grounds of the hotel are beautiful. The meals in the dining room were very good and the service was great. The only complaint the I have is that the bed mattress was extremely worn and uncomfortable. The Lodge needs new mattresses."
The price is $129
$144 total
includes taxes & fees
Jul 3 - Jul 4
The Lodge at Wakulla Springs
Best Western Wakulla Inn & Suites
2.5 star property
8.8 out of 10, Excellent, 822 reviews
"Worth the drive from FSU!! Lovely hotel, spacious, gorgeous rooms and we had 4 rooms for our family that were perfect. Beds were comfy, jacuzzi tub in the bathroom, first class all the way. Luckily we booked 8 months in advance so we got a good rate. A bit of price gouging for graduation time but not as bad as in Tallahassee! Very enjoyable stay and I highly recommend it!"
The price is $116
$129 total
includes taxes & fees
Jun 23 - Jun 24
Best Western Wakulla Inn & Suites
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The Panacea Motel
2.0 star property
9.4 out of 10, Exceptional, 25 reviews
"Beautiful 50’s-ish-retro-roadside-motel. Recently renovated and very well done.There are some snacks/drinks in the room available for purchase, very thoughtful. Didn’t anticipate this so we brought our own for an overnight stay. Easy access to a marshy scenic area by the bay on a 650’ walking trail. Might be fishable with a kayak? Basically an Air BnB situation: “No on-site staff” ."
The price is $137
$152 total
includes taxes & fees
Jun 9 - Jun 10
The Panacea Motel
Shell Point Beach 2BR condo with marina views
10.0 out of 10, Exceptional, 8 reviews
"We stayed at this property while visiting Tallahassee for an FSU game, and found this gem about 40 minutes away from the stadium. The property is at the top of what seems to be an apartment complex with about 7 other units with tenants. It is a small unit, with a very cohesive interior design with beautiful updated fixtures. The unit itself was very clean and tidy. The inside space is a bit on the small side, but there is a very good use of space. The surrounding area was very quiet and peaceful...
Shell Point Beach 2BR condo with marina views
Relax on a Beautiful River in a Natural Florida Setting
10.0 out of 10, Exceptional, 204 reviews
"t. Marks Retreat at the St. Marks River is a hidden gem nestled in nature's embrace, offering a serene escape from the hustle and bustle of everyday life. Our stay there was nothing short of delightfull. From the moment we arrived, we where captivated by the tranquil beauty that surrounded us. The St. Marks River meandering added a sense of tranquility, and the lush greenery enveloping the retreat provided a soothing backdrop for relaxation. The accommodations at St. Marks Retreat were...
Relax on a Beautiful River in a Natural Florida Setting
No cleaning fee! Family friendly home on 2 acres close to the beautiful beaches
The price is $225
$283 total
includes taxes & fees
Jun 10 - Jun 11
No cleaning fee! Family friendly home on 2 acres close to the beautiful beaches
Authentic log Cabin By the Bay.
10.0 out of 10, Exceptional, 12 reviews
"The property is beautiful and peaceful. Large enough for family to spread out. Nice place to unplug and reconnect with family. The large yard is a huge plus for parking and boats. Boat ramp just down the road."
Authentic log Cabin By the Bay.
CONDO Water front, bay breeze, fishing paradise and family friendly 2 bedroom
9.4 out of 10, Exceptional, 78 reviews
"We enjoyed the condo. We are older so it would have been nice to have choice of ground floor or stairs. Stairs were a challenge. Nice decks front and rear."
CONDO Water front, bay breeze, fishing paradise and family friendly 2 bedroom
Perfect Getaway
10.0 out of 10, Exceptional, 30 reviews
"This was our 3rd time renting this house. We love the quiet beach community. The house is great and had everything we need. We felt right at home."
Perfect Getaway
Shell Point Beach! Newly Renovated, Bay, Beach, Pool, Fishing, Dock, Golf Cart!
9.0 out of 10, Wonderful, 80 reviews
"Great stay!! We never got to access a working golf cart, but we had a great time regardless! "
Shell Point Beach! Newly Renovated, Bay, Beach, Pool, Fishing, Dock, Golf Cart!
Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf
10.0 out of 10, Exceptional, 57 reviews
"Perfect place for a perfect weekend getaway. This was one of the best VRBOs I have stayed in. The back porch was so large and comfortable. The layout of the home is so comfortable and the rooms are huge. Master bathroom was gorgeous and good for anyone with mobility issues. Food trucks came to the beach area for lunch , which was also a plus. We wanted a comfortable - low key place and we found it! I could go on and on awesome rental!"
The price is $135
$319 total
includes taxes & fees
Jun 18 - Jun 19
Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf
Cabin Located in a Birding and Fishing Paradise
9.8 out of 10, Exceptional, 115 reviews
"Ms Carolyn and Floyd were great hosts and coordination from them was great ! The place was nice and clean ! Peaceful, woodsy andsecluded , has neighbors in the distance! The hosts checked on us for arrival and we spoke to them on departure, friendly and just good folks ! We will definitely book with them again ! P.S. the fur babies also loved the fenced back yard and bbq area !"
Cabin Located in a Birding and Fishing Paradise
Coastal Getaway on canal-steps to the beach
10.0 out of 10, Exceptional, 29 reviews
"Loved the house."
Coastal Getaway on canal-steps to the beach
Enjoy Crawfordville downtown convenience at the Courtyard’s Pelican Cottage.
10.0 out of 10, Exceptional, 83 reviews
"Convenient location, property well maintained, have an orchard with variety of fruit to pick, cottage cozy very clean. Stocked with everything you need. Yard games & indoor games, books to read. Hosts Kevin & Rena did a wonderful job with this cottage. Hosts contacted us before we arrived & making sure if we needed anything to let them know. Will stay again & highly recommended this place. 👌"
The price is $90
$188 total
includes taxes & fees
Jun 18 - Jun 19
Enjoy Crawfordville downtown convenience at the Courtyard’s Pelican Cottage.
Blue Heron House, Blue Heron House
10.0 out of 10, Exceptional, 15 reviews
"Very nice and clean. Close to the community pool and pickleball courts."
Blue Heron House, Blue Heron House
Florida Abode - Private Beach Access & Ocean Views
10.0 out of 10, Exceptional, 3 reviews
"Beautiful relaxing and peaceful great place"
Florida Abode - Private Beach Access & Ocean Views
Waterfront -Beautiful sunsets, great fishing, scalloping & bird watching
10.0 out of 10, Exceptional, 35 reviews
"Great location if you like fishing and is close to the beach. Our anniversary was fantastic at this location."
Waterfront -Beautiful sunsets, great fishing, scalloping & bird watching
Luxury Suite: * Serene Nature & Spring*!!
10.0 out of 10, Exceptional, 8 reviews
"Great place. Host responded quickly. Beautiful property. Quiet. Loved everything."
The price is $145
$277 total
includes taxes & fees
Jun 10 - Jun 11
Luxury Suite: * Serene Nature & Spring*!!
Waterfront Panacea Vacation Rental w/ Dock!
8.8 out of 10, Excellent, 3 reviews
"Great location in Panacea, very clean house, quiet neighborhood, beautiful views and close proximity to Mashes beach"
Waterfront Panacea Vacation Rental w/ Dock!
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Panacea Travel Info

Number of reviews
1,149
Accommodation
435 hotels
Highest price
$225
Lowest price
$90
Reasons to visit
Shell Point Beach, Alligator Point Beach and Bald Point State Park
Hotels with nearby beaches
10
Hotels with nearby hiking
8

Frequently asked questions

Where is the best place to stay in Panacea?

Based on Expedia's traveler preferences, The Panacea Motel is a top place to stay in Panacea. Other good choices for your visit include Oceanfront Retro Beach Home on the Gulf! New Windows in 2024 to Enjoy the Views and Old Florida Beach Bungalow. See all available top hotels, or vacation rentals in Panacea.

What's the top vacation rental in Panacea?

Oceanfront Retro Beach Home on the Gulf! New Windows in 2024 to Enjoy the Views: Visitors give good reviews to this Panacea vacation home rental, which is located by the ocean and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the books in this rental home to help you unwind. Our travelers also rate Old Florida Beach Bungalow as a favorite home for rent in Panacea. See all vacation rentals in Panacea.

If I need to cancel my hotel reservation in Panacea, will I receive a refund?

Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.

Where can I learn more about changing or cancelling my trip to Panacea?

For more details about changing or cancelling your trip to Panacea, click here.

What's the best pet-friendly place to stay in Panacea?

The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.

Where is the best hotel to stay with easy access to USS Mohawk CGC Veterans Memorial Reef?

Best Western Wakulla Inn & Suites is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. You'll find it 5.7 mi (9.1 km) from USS Mohawk CGC Veterans Memorial Reef. Another good option is Magnuson Hotel Wildwood Inn, located 6.5 mi (10.5 km) away.

What are some accommodations with pools in Panacea?

Waterfront Oasis with Pool, Golf Cart, Tennis Court & Lots of Free Amenities: Offers sun loungers, a communal pool, and complimentary wireless internet access. View all hotels with pools in Panacea.

What is the best spa hotel in Panacea?
What's the best hotel for staying near Tallahassee Regional Airport (TLH)?

Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.

What's it like to stay in Panacea?

Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 162 hotels and other accommodations to choose from. Find out more about Panacea.

What are the top places to visit in Panacea?

Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach, and Bald Point State Park. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Panacea Springs and Porter Island. Check out what more to see and do in Expedia's Panacea guide.

What's the seasonal weather like in Panacea?

The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.

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